I don't know if the number of 2-out hits allowed with RISP is a factor in a team's success, or lack thereof, but it would seem to make sense. If you can limit scoring by getting out of innings when the opportunity is there, you would think you should be in better shape than others. Obviously, hits dropping in can be the product of luck, so this probably can't accurately determine the effectiveness of a staff, but it seemed worth a look.
The Tigers have given up 54 hits with 2 outs and RISP; only Colorado, with 56, is worse in MLB. Furthermore, Detroit only has 22 strikeouts in those situations, the worst in MLB. This would seem significant to me.
Cleveland has yielded the lowest number of hits with 2 outs and RISP, with 24. Toronto (28), Baltimore (29) and the Cubs (30) and Rays (30) follow. Of that group, only Toronto has a losing record, and the Blue Jays' ERA is 3.56, which is fourth best in MLB.
Joining Detroit and Colorado in the bottom 5 are Pittsburgh, Texas, and the White Sox.